279 The use of PRP to target dysregulated pathways in androgenetic alopecia
نویسندگان
چکیده
Androgenetic alopecia (AGA) is the most common type of progressive hair loss; however, its treatment remains limited in scope, thus driving need for alternative therapies restoration. The pathogenesis androgenetic not completely understood but involves disruption Wnt/β-catenin signaling pathway, resulting premature termination anagen growth phase follicles. This manifests clinically as transformation terminal into thinner vellus-like hair, a process known follicle miniaturization. Platelet rich plasma (PRP) has recently been regarded novel AGA. PRP an autologous preparation that contains supraphysiologic concentrations platelets and their associated factors, which have implicated regulating growth. Nevertheless, extensive variabilities administration protocols makes it difficult to interpret clinical efficacy treating study follows previous review from our group 2018 by Cervantes et al. analyze discuss recent trials use We included those assessed combination or direct comparison with standard care AGA, namely minoxidil and/or finasteride. thoroughly examined summarized methodologies fifteen original published between October 2021. Of studies, five evaluated combined compared effects treatment, seven established effective AGA alone, three concluded ineffective By rigorously analyzing each trial, we aim provide overall consensus on how can be best used
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Inflammation in androgenetic alopecia
Years of research have led to the conclusion that androgenetic alopecia may be a result of an alteration in the hair growth cycle and/or a premature aging of the pilosebaceous unit. The etiology of androgenetic alopecia has been defined as multifactorial or even polygenic in nature. The fact that the success rate of treatment with either antihypertensive agents or modulators of androgen metabol...
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15 صفحه اولMale androgenetic alopecia.
IMPORTANCE OF THE FIELD Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern. Hair loss results in reduced self esteem, loss of confidence and anxiety in affected men. An effective treatment for hair baldness would be desirable. AREAS COVERED IN THIS REVIEW In and...
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Rationale:Androgenetic alopecia is not considered a life threatening disease but can have serious impacts on the patient's psychosocial life. Genetic, hormonal, and environmental factors are considered responsible for the presence of androgenetic alopecia. Recent literature reports have proved the presence of inflammation and also of oxidative stress at the level of dermal papilla cells of pati...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.287